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姓名  
崔成森
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研究员
学历  
博士研究生
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cuichs@tib.cas.cn
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天津市空港经济区西七道32号
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300308

简历

2007-2011年,西北农林科技大学,学士 

2011-2015年,英国布里斯托化学院,博士,有机与生物化学 

2015-2017年,香港科技大学化学系,助理研究员 

2017-2018年,美国哈佛大学化学与化学生物学系,博士后

2018-2021年,美国普渡大学化学与癌症研究中心,博士后

2022-至今,中国科学院天津工业生物技术研究所,研究员

研究方向:
  
 
主要研究方向为挖掘并改造天然产物生物合成途径中的酶分子,通过理性设计赋予其高转化率、高区域和立体选择性。开发以人工酶介导的新颖酶促反应,发展化学-酶法药物分子的绿色、可持续、高效的合成新路线,并积极推进产业化。
 
代表论著:
 

   

参与合成的目标天然产物分子

 

1.  Zhang, J.; Liao, D.; Chen, R.; Zhu, F.; Ma, Y.; Gao, L.; Qu, G.; Cui, C.; Sun, Z.;* Lei, X.;* Gao, S.* Tuning Imine Reductase for Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering. Angew. Chem. Int. Ed., 2022, e202201908. 

2.   Li, H.; Younes, S. H. H.; Chen, S.; Duan, P.;* Cui, C.; Ron Wever, R.; Zhang, W.;* Hollmann, F.;* A chemoenzymatic Hunsdiecker-type decarboxylative bromination of cinnamic acids. ACS Catal., 2022, Manuscript Accepted.

3.   Cui, C.; Dwyer, B. G.; Liu, C.; Abegg, D.; Yin, X.; Hoch, D.; Cai, Z.; Qiu, N.; Liu, J.; Adibekian, A.; Dai, M.* Total synthesis and chemoproteomics connect curcusone diterpenes with oncogenic protein BRAT 1. J. Am. Chem Soc. 2021, 143, 4379. (co-first author). 

4.   Wang. Y.; Cui, C.; Dai, M.* Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A. Angew. Chem. Int. Ed. 2021, 60, 24828. (co-first author). 

5.   H Raffa, N.; Won, T. H.; Sukowaty, A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.;* Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper suffiency and exhibit antimicrobial activity. Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118. 

6.  Cui, C.; Lai, Y.; Dai, W.-M.* Multimodule Assembly Strategy for Diverted Total Synthesis and Stereochemical Determination of Laingolide A and Laingolide. ChemRxiv posted on 05.04.2021. [DOI: 10.26434/chemrxiv.14347145.v1]. (co-first author). 

7.   Cui, C.; Dai, W.-M.* Total synthesis of laingolide B stereoisomers and assignment of absolute configuration. Org. Lett. 2018, 20, 3358. 

8.   Thistlethwaite, I. R. G.; Bull, F. M.; Cui, C.; Walker, P. D.; Gao S.-S.; Wang, L.; Song Z.; Masschelein, J.; Lavigne, R.; Crump, M. P.; Race, P. R.; Simpson, T. J.; and Wills, C. L.* Elucidation of the relative and absolute stereochemistry of the Kalimantacin/batumin antioiotics. Chem. Sci., 2017, 8, 6196. 

9.   Shi, J.; Wu, J.; Cui, C.; Dai, W.-M.* Microwave-Assisted Iintramolecular Ullmann diaryl etherification as the Post-Ugi annulation for generation of dibenz[b,f][1,4]oxazepine scaffold. J. Org. Chem. 2016, 81, 10392. 

10.  Zhang, J.*; Cui, C.; Chen, H.; Liu, J. The completion of esterification of free fatty acids in Zanthoxylum bungeanum seed oil with ethanol. International Journal of Green Energy, 2014, 11, 822. 

申请专利:

1. Dai, M.; Adibekian, A., Cui, C.; Dwyer, B. G.; Cai, Z.; The synthesis of curcusone derivatives. U.S. 63/084,594.


承担科研项目情况:
  

获奖及荣誉: