致力于生物过程工程研究，研究内容涵盖生物反应器流场模拟、生物反应器设计、发酵过程优化、发酵过程放大、生物发酵过程的数值模拟与理性放大技术开发等。具体的研究方向包括：
- 生物反应器流场研究
- 新型反应器开发与应用
- 发酵过程优化与放大技术
- 发酵过程的数值模拟与智能控制技术
- 发酵过程的组学大数据分析及建模
代表论著：
1. Peng Liu, Ye Hua, Wei Zhang, Tingting Xie, Yingping Zhuang*, Jianye Xia*, Henk Noorman, 2021, A new strategy for dynamic metabolic flux estimation by integrating transient metabolome data into genome-scale metabolic models, Bioprocess and Biosystems Engineering, 44, 2553–2565.
2. Peng Liu, Shuai Wang, Chao Li, Yingping Zhuang, Jianye Xia*, Henk Noorman, 2021，Dynamic response of Aspergillus niger to periodical glucose pulse stimulus, Biotechnology and Bioengineering, 118(6):2265-2282.
3. Jingru Zhou, Yingping Zhuang, Jianye Xia*, 2021, Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions, Microbial Cell Factories, 20: 125.
4. Chao Li, Xiaonuo Teng, Huadong Peng, Xiaoping Yi, Yingping Zhuang, Siliang Zhang, Jianye Xia*, 2020, Novel scale-up strategy based on three-dimensional shear space for animal cell culture, Chemical Engineering Science, 212, 115329.
5. Shuai Wang, Peng Liu, Wei Shu, Chao Li, Huan Li, Shanshan Liu, Jianye Xia*, Henk Noorman, 2019, Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations, Bioresources and Bioprocessing, 6(16).
6. Chao Li, Jiangtao Tian, Weifei Wang, Huadong Peng, Ming Zhang, Haifeng Huang, Siliang Zhang, Jianye Xia*, 2019, Numerical and experimental assessment of a miniature bioreactor equipped with a mechanical agitator and non-invasive biosensors, Journal of Chemical Technology and Biotechnology, 94(8): 2671-2683.
7. Chao Li, Wei Shu, Shuai Wang, Peng Liu, Ying-Ping Zhuang, Si-Liang Zhang, Jian-Ye Xia*, 2018, Dynamic metabolic response of Aspergillus niger to glucose perturbation: evidence of regulatory mechanism for reduced glucoamylase production, Journal of Biotechnology, Aug 19; 287:28-40.
8. Han Wang, Jian-Ye Xia*, Zhi-Ming Zheng*, Ying-Ping Zhuang, Xiao-Ping Yi, Da-He Zhang, Peng Wang, 2018, Hydrodynamic investigation of a novel shear-generating device for the measurement of anchorage-dependent cell adhesion intensity, Bioprocess and Biosystems Engineering, 41(9):1371-1382.
9. Ao Pan, Ming-Hui Xie, Jian-Ye Xia*, Ju Chu, Ying-Ping Zhuang*, 2018, Gas-liquid mass transfer studies: The influence of single- and double-impeller configurations in stirred tanks, Korean Journal of Chemical Engineering, 35(1):61-72.
10. Ao Pan, Ming-Hui Xie, Chao Li, Jian-Ye Xia*, Ju Chu, Ying-Ping Zhuang, 2017, CFD simulation of average and local gas-liquid flow properties in stirred tank reactors with multiple Rushton impellers, Journal of Chemical Engineering of Japan, 50(12):878-891.
11. Hongzhong Lu, Chao Li, Wenjun Tang, Zejian Wang, Jianye Xia*, Siliang Zhang, Yingping Zhuang, Ju Chu*, Henk Noorman, 2015, Dependence of fungal characteristics on seed morphology and shear stress in bioreactors, Bioprocess and Biosystems Engineering, 38(5):917-928.
12. Wenjun Tang, Ao Pan, Hongzhong Lu, Jianye Xia*, Yingping Zhuang, Siliang Zhang, Ju Chu*, Henk Noorman, 2015, Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer, Biochemical Engineering Journal, 99(15):167-176.
13. Ming-Hui Xie, Jian-Ye Xia*, Zhen Zhou, Guo-Zhong Zhou, Ju Chu, Ying-Ping Zhuang, Si-Liang Zhang, Henk Noorman, 2014, Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions, Chemical Engineering Science, 106:144-156.
14. Jian-Ye Xia, Si-Jing Wang, Si-Liang Zhang, Jian-Jiang Zhong, 2008, Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor, Biochemical Engineering Journal, 38(3): p.406-413.
15. Jian-Ye Xia, Yong-Hong Wang, Si-Liang Zhang, Ning Chen, Peng Yin, Ying-Ping Zhuang, Ju Chu, 2009, Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment, Biochemical Engineering Journal, 43(3):p.252-260.
