利用合成生物学和代谢工程技术，围绕重要酶、结构蛋白及活性聚合物的微生物合成开展基础及应用研究。设计构建蛋白纳米支架，组装多酶反应器，实现高附加值化合物的体内外合成。在Nature Communications、Metabolic Engineering、Carbohydrate Polymers、Microbial Cell Factories等期刊发表论文29篇，申请专利13项，授权5项。
代表论著：
1. Sijia Wang, Wenxin Huang, Zhaoxuan Feng, Xiaoli Tian, Dexin Wang, Lang Rao, Ming Tan, Niran Roongsawang, Hui Song*, Wenxia Jiang*, Wenqin Bai*. Laccase-mediated formation of hydrogels based on silk-elastin-like protein polymers with ultra-high molecular weight. International Journal of Biological Macromolecules. 2023, 231:123239. DOI: 10.1016/j.ijbiomac.2023.123239. (IF 8.025)
2. Shuyu Chen, Hongchen Zheng, Jiaqi Gao, Hui Song, Wenqin Bai*. High-level production of pullulan and its biosynthesis regulation in Aureobasidium pullulans BL06. Frontiers in Bioengineering and Biotechnology. 2023, DOI：10.3389/fbioe.2023.1131875. (IF 6.064)
3. Yifan Yang, Xiaoping Fu, Xingya Zhao, Jianyong Xu, Yihan Liu *, Hongchen Zheng *, Wenqin Bai*, Hui Song. Overexpression of a thermostable α-amylase through genome integration in Bacillus subtilis. Fermentation. 2023, Accept. (IF 5.123)
4. Dexin Wang, Xiaoping Fu, Dasen Zhou, Jiaqi Gao, Wenqin Bai*. Engineering of a newly isolated Bacillus tequilensis BL01 for poly-γ- glutamic acid production from citric acid. Microbial Cell Factories. 2022, 21(1):276. DOI: 10.1186/s12934-022-01994-z. (IF 6.352)
5. Zhaoxuan Feng, Jinsong Li, Dasen Zhou, Hui Song, Jiaqi Lv*, Wenqin Bai*. A novel photocurable pullulan-based bioink for digital light processing 3D printing. International Journal of Bioprinting. 2022, 9(2). DOI: 10.18063/ijb.v9i2.657. (IF 7.422)
6. Zhaoxuan Feng, Shuyu Chen, Abdullah Ahmad, Longjiao Chen, Wenqin Bai*. Ultra-high molecular weight pullulan-based material with high deformability and shape-memory properties. Carbohydrate Polymers. 2022, 295:119836. DOI: 10.1016/j.carbpol.2022.119836. (IF 10.723)
7. Wenqin Bai, Winston E. Anthony, Christopher Hartline, Shaojie Wang, Bin Wang, Jie Ning, Fong-Fu Hsu, Gautam Dantas*, Fuzhong Zhang*. Engineering Diverse Fatty Acid Compositions of Phospholipids in Escherichia coli. Metabolic Engineering. 2022, 74:11-23. DOI: 10.1016/j.ymben.2022.08.011. (IF 8.829)
8. Wenqin Bai, Cameron J. Sargent, Jeong-Mo Choi, Rohit V. Pappu, Fuzhong Zhang*. Covalently-assembled single-chain protein nanostructures with ultra-high stability. Nature Communications. 2019, 10, 3317. doi://doi.org/10.1038/s41467-019-11285-8. (IF 17.694)
9. Wenqin Bai, Weitao Geng, Shaojie Wang and Fuzhong Zhang*. Biosynthesis, regulation, and engineering of microbially produced branched biofuels. Biotechnology for Biofuels. 2019, 12:84. (IF 7.67)
10. Christopher H. Bowen, Bin Dai, Cameron J. Sargent, Wenqin Bai, Pranay Ladiwala, Huibao Feng, Wenwen Huang, David L. Kaplan, Jonathan M. Galazka, Fuzhong Zhang*. Recombinant spidroins fully replicate primary mechanical properties of natural spider silk. Biomacromolecules, 2018, 19, 3853-3860. (IF 6.978)
11. Jingyu Wang, Jilong Wang, Yi-shu Tai, Qiuge Zhang, Wenqin Bai, Kechun Zhang*. Rerouting carbon flux for optimized biosynthesis of mesaconate in Escherichia coli. Applied Microbiology and Biotechnology. 2018, 102(17): 7377-7388. (IF 5.560)
12. Wenqin Bai, Yi-Shu Tai, Jingyu Wang, Jilong Wang, Pooja Jambunathan, Kevin J. Fox, Kechun Zhang*. Engineering Nonphosphorylative Metabolism to Synthesize Mesaconate from D-Xylose and L-Arabinose in Escherichia coli. Metabolic Engineering, 2016 (38): 285–292. (IF 8.829)
13. Wenqin Bai*, Yufan Cao, Jun Liu, Qinhong Wang, Zhenhu Jia. Improvement of alkalophilicity of an alkaline xylanase Xyn11A-LC from Bacillus sp. SN5 by random mutation and Glu135 saturation mutagenesis. BMC Biotechnology, 2016(16):77 (IF 3.329)
14. Jilong Wang, Suthamat Niyompanich, Yi-Shu Tai, Jingyu Wang, Wenqin Bai, Prithviraj Mahida, Tuo Gao and Kechun Zhang*. Engineering Highly Efficient E. coli strain for Mevalonate Fermentation by Chromosomal Integration. Applied and Environmental Microbiology, 2016, 82(24):7176-7184. (IF 5.005)
15. Wenqin Bai, Yanfen Xue, Yueju Zhao, Qinhong Wang, Yanhe Ma*. Structural insight into and mutational analysis of family 11 xylanases: implications for mechanisms of higher pH catalytic adaptation. PLoS One. 2015, Jul 10, 10(7):e0132834. (IF 3.752)
16. Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. Cloning, expression and characterization of an alkali-tolerant xylanase from alkalophilic Bacillus sp. SN5. Biotechnol Appl Biochem. 2015, 62(2):208-17. (IF 2.724)
17. Wenqin Bai, Cheng Zhou, Yanfen Xue, Chunhsiang Huang, Ruiting Guo, Yanhe Ma*. Three-dimensional structure of an alkaline xylanase Xyn11A-LC from alkalophilic Bacillus sp. SN5 and improvement of its thermal performance by introducing arginines substitutions. Biotechnol Lett. 2014, 36(7):1495-501. (IF 2.716)
18. Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. Cloning, expression and characterization of a novel salt-tolerant xylanase from Bacillus sp. SN5. Biotechnol Lett. 2012, 34(11):2093-9. (IF 2.716)
19. Qiuzan Zhong, Haiyan Zhang, Wenqin Bai, Mei Li, Baotong Li, Xinghui Qiu*, Degradation of aromatic compounds and degradation pathway of 4-nitrocatechol by Ochrobactrum sp. B2. Journal of Environmental Science and Health, Part A. 2007, 42: 2111-2116. (IF 2.582)
20. Xinghui Qiu*, Qiuzan Zhong, Mei Li, Wenqin Bai, Baotong Li. Biodegradation of p-nitrophenol by methyl parathion-degrading Ochrobactrum sp. B2. International Biodeterioration & Biodegradation. 2007, 59 (4): 297-301. (IF 4.907)
21. Xinghui Qiu*, Wenqin Bai, Qiuzan Zhong, Mei Li, Fengqin He and Baotong Li. Isolation and characterization of a bacterial strain of the genus Ochrobactrum with methyl parathion mineralizing activity. Journal of Applied Microbiology. 2006, 101,986-994. (IF 4.059)
专利：
申请专利13项，已授权5项。
