主要研究方向为生物催化、酶工程、酶固定化以及功能性分子合成。具体研究方向如下:
1. 生物催化的手性氧化还原反应,利用半乳糖氧化酶等酶催化的手性拆分、去消旋化反应进行复杂分子的合成;
2. 轴手性化合物的生物催化转化反应,利用酶催化或级联反应进行轴手性化合物的合成;
3. 纳米杂合酶固定化体系创制与应用,利用新型功能性纳米材料进行杂合体系创制与反应扩大化及其应用研究。
代表论著
1. B. Yuan, D. Mahor, Q. Fei, R. Wever, M. Alcalde, W. Zhang, F. Hollmann, Water-Soluble Anthraquinone Photocatalysts Enable Methanol Driven Enzymatic Halogenation and Hydroxylation Reactions, ACS Catalysis, 2020, 10, 8277-8284.
2. B. Yuan, D. Debecker, X. Wu, J. Xiao, Q. Fei, N. J. Turner, One‐pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation, Chemcatchem, 2020, 12, 6191-6195
3. B. Yuan, A. Page, C. P. Worrall, F. Escalettes, S. C. Willies, J. J. W. McDouall, N. J. Turner and J. Clayden, Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases, Angewandte Chemie International Edition, 2010, 49, 7010-7013.
4. B. Yuan, F. Escalettes, and N. J. Turner, Practical Methods for Biocat. and Biotrans. 2, Chapter 6.2, Selective Enzymatic Oxidation of Atropisomeric Diaryl Ethers by Oxidation with Oxygen and Catalytic Galactose Oxidase M3-5; Chapter 6.3, Kinetic Resolution of Chiral Secondary Alcohol by Oxidation with Oxygen and Catalytic Galactose Oxidase M3-5, 2012, John Wiley & Sons, Ltd.
5. Staniland, S., B. Yuan, Giménez-Agulló, N., Marcelli, T., Willies, S. C., Grainger, D. M., N. J. Turner, Clayden, J. Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers, Chemistry: A European Journal, 2014, 20, 13084-8.